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Four Horsemen

First Appearance: Ascension, Part One
The leader of Hydra, Madame Hydra was the one responsilble for cloning Wolverine and creating X23. X23 hated her for this, and gave it her all trying to find her. After tricking Wolverine into helping her find the MH, X2 managed to blow up their main headquarters. Madame Hydra managed to get away though, leaving X23 without her revenge.