The web-crawler returns in this Spider-Man adventure based on the The Amazing Spider-Man motion picture. Created as an epilogue story occurring entirely after the events of the movie, the game features the return of free-roaming web-slinging all over the city and evolutionary improvements to navigation and combat, as the newly anointed Spider-Man is plunged into an all-new storyline charged with protecting Manhattan from a variety of criminals.

New York City is infected! Dr. Curt Connors - aka The Lizard - is in a mental hospital after the events of the movie. When his work at Oscorp with different cross-species comes to light and they break free, infecting others with an illness through mere touch, new Oscorp science head Allistair Smythe invents robots to kill the cross-species and the infected New Yorkers. Spidey must team up with Conners and Gwen Stacey to stop a horde of genetic creatures and save the city!

Using the game's new Web Rush mechanic, players can pull off a vast array of moves never before possible. With a story that takes players through many areas all over (and under) Manhattan, fans will feel what it's truly like to be a Super Hero, as they experience the cinematic adrenaline rush of web-swinging through the city and fighting crime using Spider-Man's spectacular acrobatic moves and attacks.